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Endocrine Abstracts

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ea0016p673 | Steroid receptors | ECE2008

Vitamin D receptor gene polymorphism influences the amplitude of 1,25(OH)2D3 immune impact

van Etten Evelyne , Verlinden Lieve , Giulietti Annapaula , Lopez Elizabeth Ramon , Branisteanu Dumitru D , Ferreira Gabriela Bomfim , Overbergh Lutgaard , Verstuyf Annemieke , Bouillon Roger , Roep Bart O , Badenhoop Klaus , Mathieu Chantal

1,25-Dihydroxyvitamin D3 (1,25(OH)2D3) influences the differentiation and cytokine secretion of various immune cell types. These immune modulating effects of 1,25(OH)2D3 are mediated through the nuclear vitamin D receptor (VDR). In the immune system, the 1,25(OH)2D3/VDR complex interacts with promoter vitamin D responsive elements (VDRE), or interferes with the signalling of other transcription factor...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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